博碩士論文 etd-0825106-102620 詳細資訊


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姓名 邱瑞祺(Jui-Chi Chiu) 電子郵件信箱 jcchiu26@ms42.hinet.net
畢業系所 國際高階經營管理碩士班(IEMBA)
畢業學位 碩士(Master) 畢業時期 94學年第2學期
論文名稱(中) 台灣新藥上市行銷策略探討—以抗憂鬱劑為例
論文名稱(英) Strategy for launching new drug to Taiwan market---case study for antidepressant
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    摘要(中) 論文提要
    生技製藥業的新產品上市是個很冗長,且耗費龐大的一個過程,但是只有一定年限的專利保護。新藥上市須考慮到藥品的療效、副作用、與安全性,也須經過主管機關的審核。新藥的行銷與銷售需透過醫院採購、醫師處方、病患服用等過程來完成,如果醫院不採購、醫師不處方、病患不適用或不服藥,整個銷售過程就會中斷。所以利用新藥上市模型來擬定新藥上市的策略是有幫助的。本研究主要是探討新藥上市模型的適用性,及利用新型抗憂鬱劑做驗證,擬定新型抗憂鬱劑的上市策略。
    新藥上市模型包含外部分析與內部分析。外部分析,主要是要做顧客分析、市場分析、競爭者分析、討論管理議題和區域議題。內部分析,在做績效分析、策略選擇分析、討論產品議題和技術議題。分析完成之後根據結果找出關鍵成功因素,參考競爭標竿,再做策略展開。
    抗憂鬱劑市場是個成熟的市場,但是仍有未被醫師及病患滿足的地方,包括低的反應率及緩解率、憂鬱症的殘餘症狀不易根除、復發率高等。新的抗憂鬱劑想要成為市場領導者,首先是療效需讓醫師及病患滿意;第二是必須快速進入各個通路,如醫院、診所、藥局;第三是要讓醫師及病人接受憂鬱症包含情緒症狀及身體症狀,是可治療的;第四是要讓憂鬱症病人出來接受治療;最後是要讓憂鬱症病人能夠完成整個治療計畫。
    整個結果顯示,新藥上市模型是個很好的策略展開工具,抗憂鬱劑市場是個成熟市場但是還有未被醫師和病人滿足的地方,新型抗憂鬱劑可切入利基市場。
    關鍵字:新藥上市模型、競爭標竿、策略、憂鬱症、抗憂鬱劑
    摘要(英) Abstract
    Although developing a new drug produced with bio-technologies is a time-consuming and costly process, the patent of such kind of new products can only be protected for only few years. Therefore, the launch for new drug can not be made without thorough consideration of the market and its environment.
    Introducing a new medicament to the market needs considering various factors, such as its efficiency, side-effects, and safety. The introduction requires also the approval from relevant government authorities.
    The sales of a new drug depend on the purchase from hospitals, the prescription from doctors and the utilization from patients to complete the process. If one of these three elements is missing, the whole process will be broken up. Therefore, it is helpful to take the sales process and its model as a reference to define the strategy for launching a new drug to the local market.
    The model to introducing a new drug includes two sides of analysis – external and internal analysis. The external analysis covers mainly areas such as studies of customers, market and competitors, it includes as well issues concerning regulatory and geography area division. The internal analysis is with focus on studies regarding efficiency, strategy alternatives, products and relevant technologies. Only after the analysis as such, the key factors for a successful marketing can be identified. Taking lessons learnt from products, the strategy can be defined accordingly and implemented.
    Today although the market for antidepressants is well developed, there are areas which remain unsatisfied by doctors and patients, inter alia, its low response and remission rate, the difficulty of a total recovery, and the high probability of relapse. Any new antidepressants, should it wish being the leading medicament in the market, the satisfaction from both users – the medical doctors and the patients – is a must. Secondly, the product must be introduced through all kind of relevant channels to reach out to actual and potential users (not necessarily those working in the hospitals and clinics). Last but not least, the society should remove any stigma on people suffering from depression and encourage them (and their relatives) to go for the treatment and complete the treatment for their own and the society’s well-being.
    Finally, new drug launch model is a useful tool for developing marketing strategy. Market of antidepressant is a mature market. Nevertheless doctors and patients remain unsatisfied vis a vis certain aspects of the antidepressant.  Any new antidepressant if it can meet the requirement, it certain has chance to enter niche market.
    Key word: new drug launch model, competitive benchmarking, strategy, depression, antidepressant
    關鍵字(中)
  • 抗憂鬱劑
  • 憂鬱症
  • 新藥上市模型
  • 策略
  • 競爭標竿
  • 關鍵字(英)
  • new drug launch model
  • antidepressant
  • strategy
  • competitive benchmarking
  • depression
  • 論文目次 目  錄
    論文提要 I
    Abstract II
    目錄 IV
    表目錄 V
    圖目錄 VI
    第一章 前言 1
    第二章 理論架構 3
    第一節 新產品上市模型 3
    第二節 競爭標竿 10
    第三章 憂鬱症概述及個案公司介紹 19
    第一節 憂鬱症概述 19
    第二節 個案公司介紹 28
    第四章 策略分析與展開 35
    第一節 外部分析 35
    第二節 內部分析 46
    第三節 生技製藥業特性 47
    第四節 機會與威脅、優勢與劣勢 58
    第五節 關鍵成功因素 60
    第六節 策略展開 61
    第五章 討論與結論 64
    第一節 討論 64
    第二節 結論 71
    第六章 參考文獻 74

    表 目 錄
    表一、抗憂鬱藥物藥費申報統計分析 28
    表二、禮來公司中樞神精用藥銷售量 33
    表三、抗憂鬱劑產品佔有率分析 38
    表四:主要抗憂鬱劑的優缺點 39
    表五、抗憂鬱產品建議劑量及價格 42
    表六、Cymbalta的SWOT分析 58
    圖 目 錄
    圖一、生技製藥業的新產品上市模型 3
    圖二、漢氏憂鬱症量表症狀比例 21
    圖三、憂鬱症療程 24
    圖四、中央健保局抗憂鬱藥物藥品申報情形 27
    圖五、禮來公司股價 34
    圖六、藥品費用成長分析 44
    圖七、藥費申報點數統計 45
    圖八、抗憂鬱藥物的發展 48
    圖九、Cymbalta對憂鬱症的改善 49
    圖十、Cymbalta對憂鬱症的緩解率 49
    圖十一、Cymbalta的治療時間對憂鬱症的改善程度 51
    圖十二、Cymbalta對焦慮症狀的改善 51
    圖十三、Cymbalta對憂鬱症伴隨疼痛的改善 52
    圖十四、Cymbalta對憂鬱症伴隨各種疼痛的改善 52
    圖十五、Cymbalta對憂鬱症病被痛的改善程度 53
    圖十六、Cymbalta長期使用對憂鬱症的緩解率 54
    圖十七、Cymbalta的副作用發生率 54
    圖十八、Cymbalta停藥後戒斷症狀的發生率 55
    圖十九、修正後的生技製藥業的新產品上市模型(新藥上市模型) 65
    參考文獻 參考文獻
    一、中文
    1. 中央健康保險局,2005。全民健康保險藥品費用成長因素分析及對總額影響。http://www.nhi.gov.tw/intro/statistic/work9403-3.ppt
    2. 中央健康保險局,2006。健保總額支付制度。http://www.nhi.gov.tw/webdata/webdata.asp?menu=9&menu_id=176&webdata_id=877
    3. 何慧敏,2005。抗憂鬱劑的使用及其影響因子──以精神疾病住院病患歸人檔〈PIMC〉為例。國立政治大學,財政所,碩士學位論文。
    4. 吳光顯、何志仁編譯,2001。精神醫學(Gelder, M.,Mayou, R., Geddes, J.,1998,Psychiatry,2/e)。台北市:藝軒圖書出版社。
    5. 孔繁鐘編譯,1997。DSM-IV精神疾病診斷與統計(American Psychiatric Association (APA),1994,The Diagnostic and Statistical Manual of Mental Disorder,The Four Edition (DSM-IV))。台北市:合紀圖書出版社。
    6. 尤丁白譯,黃恆獎審定,2005。行銷管理〈Best, R. J.,2004,Market-Based Management,4th edition〉。台北市:台灣培生教育出版股份有限公司。
    7. 方世榮譯,2003。行銷管理學〈Kotler, P.,2002,Marketing Management,11th edition〉。台北市:台灣東華書局股份有限公司。
    8. 曾條昌,2005。全民健保新藥给付績效評估之研究。國立台灣大學,高階公共管理組,碩士學位論文。
    9. 林式榖,2006。精神藥物手冊(第二版)。台北市:合紀圖書出版社。
    10. 林隆儀譯,2005。策略行銷管理〈Aaker, D. A.,2004,Strategic Market Management,7th edition〉。台北市:華泰文化事業股份有限公司。
    11. 楊延光、鄭淑惠,2006。全方位憂鬱症防治手冊。台北市:張老師文化事業股份有限公司。
    12. 楊雅雯,2005。藥師介入憂鬱症治療成效評估。國立成功大學,臨床藥學研究所,碩士學位論文。
    13. 沈武典,2004。二十一世紀臨床精神藥物學(修定版)。台北市:合紀書局有限公司。
    14. 熊心如,2005。全民健保總額支付制度與醫病關係之影響──某醫學中心之個案研究。東海大學,管理碩士學程在職進修專班,碩士學位論文。
    15. 蔡述信,2003。以台灣全民健保承保抽樣歸人檔分析憂鬱症病患的醫療利用。中國醫藥學院,醫務管理研究所,碩士學位論文。
    16. 蘇東平、陳曾基、黃信彰、周麗芳、范佩真、和陳育群,2002。台灣精神治療藥品的利用情形:西元2000年門診部門綜覽。中華醫學雜誌,65: 378-391。
    17. 黃崇銘,1997。原開發藥廠新藥上市程序與其智慧財產權保護功能之初探。國立交通大學,管理科學研究所,碩士學位論文。
    二、英文
    1. Ahn, M. J. and Dornbusch, D., 2004. Competency-based benchmarking: Revolutionizing biopharmaceutical product launches. Benchmaking: An international Journal, 11 (2): 190-202.
    2. American Psychiatry Association (APA), 2000. Practice guideline for the treatment of patients with major depressive disorder (revision). Am J Psychiatry, 157 (4 Suppl): 1-45.
    3. Andrews, G., Sanderson, K., Corry, J., and Lapsley, H. M., 2000. Using epidemiological data to model efficacy in reducing the burden of depression. J Ment Health Policy Econ, 3 (4): 175-186
    4. Brannan, S. K., Mallinckrodt, C. H., Detle, M. J., Watkin, J. G., and Tollefson, G. D., 2005. Onset of action for duloxetine 60 mg once daily: double-blind, placebo-controlled studies. J Psychiatr Res, 39 (2): 161-172.
    5. Brekke, K. R. and Kuhn, M., 2006. Direct to customer advertising in pharmaceutical markets. Journal of Health Economics, 25: 102-130.
    6. Bull, S. A., Hunkeler, E. M., Lee, J. Y., Rowland, C. R., Williamson, T. E., Schwab, J. R., and Hurt, S. W., 2002. Discontinuing or switching selective serotonin-reuptake inhibitors. Ann Pharmacother, 36 (4): 578-584.
    7. Butler, R., Collons, E., Katona, C. and Orrell, M., 2000. How do general practitioners select antidepressants for depressed elderly people? Int J Geriatr Psychiatry, 15 (7): 610-613.
    8. Bymaster, F. P., Beedle, E. E., Findlay, J., Gallagher, P. T., Krushinski, J. H., Mitchell, S., Robertson, D. W., Thompson, D. C., Wallace, L., and Wong, D. T., 2003. Duloxetine (CymbaltaTM), a dual inhibitor of serotonin and norepinephrine reuptake. Bioorganic & Medicinal Chemistry Letters, 13: 4477-4480.
    9. Corruble, E., and Guelfi, J. D., 2000. Pain complaints in depressed inpatients. Psychopathology, 33 (6): 307-309.
    10. Corstjens, M., Demeire, E., and Horowitz, I., 2005. New-product success in the pharmaceutical industry: how many bites at the cherry? Econ Innov New techn, 14 (4): 319-331.
    11. Datamonitor, 2004a. Gleevec case study: The benefits of aggressive pre-launch marketing in an immature market. Reference code: BPCS15.
    12. Datamonitor, 2004b. Nexium case study: Focusing a launch strategy on switching existing prescriptions. Reference code: BPCS22.
    13. Datamonitor, 2004c. Singulair case study: Building a successful launch strategy through clinical differentiation. Reference code: BPCS04.
    14. De La Cuevas, C., Sanz, E. J., and De La Fuente, J. A., 2002. Variations in antidepressant prescribing practice: clinical need or market influence? Pharmaciepidemiol Drug Saf, 11 (6): 515-522.
    15. Depont, F., Rambelomanana, S., Le Puil, S., Begaud, B., Verdoux, H., and Moore, N., 2003. Antidepressants: psychiatrists’ opinions and clinical practice. Acta Psychiatr Scand, 108(1): 24-31.
    16. Detke, M. J., Lu, Y., Goldstein, D. J., Hayes, J. R., and Demitrack, M. A., 2002a. Duloxetine, 60 mg once daily, for major depressive disorder: a randomized double-blind placebo-controlled trial. J Clin Psychiatry, 63 (4): 308-315.
    17. Detke, M. J., Lu, Y., Goldstein, D. J., McNamara, R. K., and Demitrack, M. A., 2002b. Duloxetine 60 mg once daily dosing versus placebo in the acute treatment of major depression. J Psychiatr Res, 36 (6): 383-390.
    18. Donohue, J. M. and Berndt, E. R., 2004. Effect of direct-to customer advertising on medication choice: the case of antidepressants. Journal o policy & Marketing, 23 (2): 115-127.
    19. Fava, M., 2002. Somatic symptoms, depression, and antidepressant treatment. J Clin Psychiatry, 63 (4): 305-307.
    20. Fava, M., Mallinckrodt, C. H., Detke, M. J., Watkin, J. G., and Wohlreich, M. M., 2004, The effect of duloxetine on painful physical symptoms in depressed patients: do improvements in these symptoms result in higher remission rates? J Clin Psychiatry, 65 (4): 521-530.
    21. Fawcett, J. and Barkin, R. L., 1997. Efficacy issues with antidepressants. J Clin Psychiatry, 58 (Suppl 6): 32-39
    22. Findlay, S. D., 2001. Direct-to-customer promotion of prescription drugs: economic implications for patients, payers and providers. Pharmacoeconomics, 19 (2): 109-119.
    23. Gallan, A. S., 2004. Factors that influence physicians’ prescribing of pharmaceuticals: a literature revies. Journal of pharmaceutical Marketing & Management, 16 (4): 3-46.
    24. Garrison, G. D. and Levin, G. M., 2000. Factors affecting prescribing of the newer antidepressants. Ann Pharmacother. 34 (1): 10-14.
    25. Geddes, J. R., Carney, S. M., Davies, C., Furukawa, T. A., Kupfer, D. J., Frank, E., and Goodwin, G. M., 2003. Relapse prevention with antidepressant drug treatment in depressive disorder: a systematic review. Lancet. 361 (9358):653-661
    26. Glass, H. E. and Poli, L. G., 2004. The dual role of company prescribing in new drug launch. Journal of pharmaceutical marketing & Management, 16 (2): 47-62.
    27. Hirschfeld, R. M., Mallinckrodt, C., Lee, T. C., and Detke, M. J., 2005. Time course of depression-symptom improvement during treatment with duloxetine. Depress Anxiety, 21 (4): 170-177.
    28. Holsboer, F., 2004. Therapeutics for depression and anxiety disorder. Drug Discovery Today: Therapeutic Strategies, 1 (1): 105-109.
    29. Hudson, J. I., Wohlreich, M. M., Kajdasz, D. K., Mallinckrodt, C. H., Watkin, J. G., and Martynov, O. V., 2005. Safety and tolerability of duloxetine in the treatment of major depressive disorder: analysis of pooled data from eight placebo-controlled clinical trials. Human Psychopharmacology: Clinical and Experimental, 20 (5): 327-341.
    30. Hultink, E. J., Hart, S. J., Robben, H. S. J., and Griffin, A. J., 1999. New consumer product launch: strategies and performance. Journal of Strategic Marketing, 7: 153-174.
    31. Huszonek, J. J., Dewan, M. J., and Donnelly, M. P., 1995. Factors associated with antidepressant choice. Psychosomatics, 36 (1): 42-47.
    32. Kroenke, K., and Price, R. K., 1993. Symptoms in the community: prevalence, classification, and psychiatric comorbidity. Arch Intern Med, 153 (21): 2474-2480.
    33. Kupfer, D. J., 1991. Long term treatment of depression. J Clin Psychiatry, 52 (Suppl): 28-34.
    34. Ladley, E., 2006. A prescription for future success. Med Ad News, 25 (2): 4-6.
    35. Lambkin, M. and Day, G. S., 1989. Evolutionary process in competitive markets: beyond the product life cycle. Journal of Marketing, 53: 4-20.
    36. Lin, E. H., Von Korff, M., Katon, W., Bush, T., Simon, G. E., Walker, E., and Robinson, P., 1995. The role of the primary care physician in patients’ adherence to antidepressant therapy. Med Care, 33 (1): 67-74.
    37. Londen, D. J. and Liebman, M., 2000. High compression marketing supercharges drug revenues. Medical Marketing and Media, 35 (3): 67-74.
    38. Meana, M., 1998. The meeting of pain and depression: comorbidity in women. Can J Psychiatry, 43 (9): 893-899.
    39. Melfi, C. A., Chawla, A. J., Croghan, T. W., Hanna, M. P., Kennedy, S., and Sredl, K., 1998. The effect of adherence to antidepressant treatment guideline on relapse and recurrence of depression. Arch Gen Psychiatry, 55 (12): 1128-1132.
    40. O’Reardon, J. P., and Amsterdam, J. D., 1998. Treatment-resistant depression: progress and limitations. Psychiatr Ann, 28: 633-640
    41. Ohayon, M. M. and Schatzberg, A. F., 2003. Using chronic pain to predict depressive morbidity in the general population. Arch Gen Psychiatry, 60: 39-47.
    42. Patel V. L., Branch, T., Mottur-Pilson, C., and Pinard, G., 2004. Public awareness about depression: the effectiveness pf a patient guideline. International Journal of Psychiatry in Medicine, 34 (1): 1-20.
    43. Paykel, E. S., Ramana, R., Cooper, Z., Hayhurst, H. Kerr, J., and Barocka, A., 1995. Residual symptoms after partial remission: an important outcome in depression. Psychol Med, 25 (6): 1171-1180.
    44. Petersen, T., Dording, C., Neault, N. B., Kornbluh, R., Alpert, J. E., Nierenberg, A. A., Rosenbaum, J. F., and Fava, M., 2002. Asurvey of prescribing practices in the treatment of depression. Prog Neuropsychopharmacol Biol Psychiatry, 26 (1): 177-187.
    45. PhRMA, 2005. Medicines in development for mental illnesses 2004. http://www.phrma.org
    46. PhRMA, 2006. Pharmaceutical industry profile 2006. http://www.phrma.org
    47. Rabheru, K., 2004. Special issues in the management of depression in older patients. Can J Psychiatry, 49 (3 Suppl 1): 41S-50S.
    48. Raskin, J., Goldstein, D. J., Mallinckrodt, C. H., and Ferguson, M. B., 2003. Duloxetine in the long-term treatment of major depressive disorder. J Clin Psychiatry, 64 (10): 1237-1244.
    49. Remick, R. A., 2002. Diagnosis and management of depression in primary care: a clinical update and review. Can Med Assoc J, 167 (11): 1253-1260
    50. Scharitzer, D. and Kollarits, H. C., 2000. Satisfied customers: profitable customer relationships: pharmaceutical marketing: how pharmaceutical sales representatives can achieve economic success through relationship management with settled general practitioners---an empirical study. Total Quality Management, 11 (7): S955-S965.
    51. Silverstein, B., 1999. Gender difference in the prevalence of clinical depression: the role played by depression associated with somatic symptoms. Am J Psychiatry, 156 (3): 480-482.
    52. Silverstein, B., 2002. Gender differences in the prevalence of somatic versus pure depression: a replication. Am J Psychiatry, 159 (6): 1051-1052.
    53. Simon, G. E., VonKorff, M., Piccinelli, M., Fullerton, C., and Ormel, J., 1999. An international study of the relation between somatic symptoms and depression. N Engl J Med, 341 (18): 1329-1335.
    54. Solomon, D., Keller, M. B., Leon, A. C., et al., 2000. Multiple recurrences of major depressive disorder. Am J Psychiarity. 157 (2):299-333.
    55. Spiller, L. D. and Wymer, W. W. Jr., 2002. Physicians’ responses to marketing strategies of pharmaceutical companies. Journal of Pharmaceutical Marketing & Management, 15 (1): 15-30.
    56. Thase, E. A., Entsuah, A. R., and Rudolph, R. L., 2001. Remission rates durning treatment with venlafaxine or selective serotonin reuptake inhibitors. Br J Psychiatry, 178 (3): 234-241.
    57. Trim, P. and Pan, H., 2005. A new product launch strategy (NPLS) model for pharmaceutical companies. European Business Review, 17 (4): 325-339.
    58. Wilson, K. G., Mikail, S. F., D’Eon, J. L., and Minns, J. E., 2001. Alternative diagnostic criteria for major depressive disorder in patients with chronic pain. Pain, 91: 227-234.
    口試委員
  • 李英俊 - 召集委員
  • 楊延光 - 委員
  • 葉淑娟 - 指導教授
  • 口試日期 2006-06-15 繳交日期 2006-08-25

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